Aberrant promoter methylation of T-cadherin in sera is associated with a poor prognosis in oral squamous cell carcinoma

T-cadherin functions as a suppressor gene, which is frequently inactivated by aberrant promoter methylation in several human cancers, but its status oral squamous cell carcinoma (OSCC) has been scarcely studied. Thus this study aimed at exploring the clinical significance and prognostic value of sera patients with OSCC. Methylation-specific PCR (MSP) bisulfate sequencing (BSP) was performed to examine T-cadherin. Then, associations between various clinicopathological variables or patient survival were investigated 202 OSCC 68 controls. detected 62 out (30.7%) OSCC, corresponding tissues confirmed BSP. Methylation significantly associated advanced tumor T-stage (P < 0.001) N-stage = 0.003), positive lymphatic metastasis 0.004) recurrence 0.001). In addition, had worse overall 0.018) progression-free than without, an independent factor for (HR: 3.626, 95% CI: 1.112-9.624, P 0.007) 4.201, 1.562-10.038, These results demonstrated that risk factors poor outcomes, may act potential marker